DOI: http://dx.doi.org/10.18203/issn.0019-5359.IndianJMedSci20170493

A case of carcinocythemia following breast carcinoma mimicking acute leukemia: a case report and review of literature

Monica Jain, Surbhi Gupta, Pragya Sukla, Alka Srivastava, R. K. Grover

Abstract


Carcinocythemia, the presence of circulating cancer cells in the peripheral blood is a rare event which occurs as a late manifestation of solid malignancies and can be confused as acute leukemia. A 50-year-old male with breast carcinoma presented to the hospital with complaints of breathlessness and weakness. His routine hemogram showed leucocytosis along with marked anemia and thrombocytopenia. The peripheral blood smear showed presence of blast like cells and a diagnosis of acute leukemia/metastatic carcinoma breast was considered. The blasts like cells were negative for myeloperoxidase stain. The bone marrow revealed presence of metastatic adenocarcinoma. Carcinocythemia was diagnosed and the patient has been planned for docetaxol and carboplatin based chemotherapy. The differential diagnosis for carcinocythemia is acute leukemia which is common following chemotherapy and radiotherapy for solid tumors. These patients generally have a poor prognosis and survival.


Keywords


Acute leukemia, Breast carcinoma, Carcinocythemia, Circulating tumor cells

Full Text:

PDF

References


Gallivan MV, Lokich JJ. Carcinocythemia (carcinoma cell leukemia). Report of two cases with english literature review. Cancer 1984;53:1100-2.

Sile CC, Perry DJ, Nam L. Small cell carcinocythemia. Arch Pathol Lab Med 1999;123:426-8.

Rodríguez-Salas N, Jiménez-Gordo AM, González E, de las Heras B, Zamora P, Espinosa E, et al. Circulating cancer cells in peripheral blood. A case report. Acta Cytol 2000;44:237-41.

Curtis RE, Boice JD Jr, Stovall M, Bernstein L, Greenberg RS, Flannery JT, et al. Risk of leukemia after chemotherapy and radiation treatment for breast cancer. N Engl J Med 1992;326:1745-51.

Duffy MJ. Serum tumor markers in breast cancer: Are they of clinical value? Clin Chem 2006;52:345-51.

Engell HC. Cancer cells in the blood; a five to nine year follow up study. Ann Surg 1959;149:457-61.

Brown CE, Warren S. Visceral metastasis from rectal carcinoma. Surg Gynec Obstet 1938;66:611.

Song J, From P, Morrissey WJ, Sams J. Circulating cancer cells: Pre- and post-chemotherapy observations. Cancer 1971;28:553-61.

Carey RW, Taft PD, Bennett JM, Kaufman S. Carcinocythemia (carcinoma cell leukemia). An acute leukemia-like picture due to metastatic carcinoma cells. Am J Med 1976;60:273-8.

Myerowitz RL, Edwards PA, Sartiano GP. Carcinocythemia (carcinoma cell leukemia) due to metastatic carcinoma of the breast: Report of a case. Cancer 1977;40:3107-11.

Beverley PC, Linch D, Delia D. Isolation of human haematopoietic progenitor cells using monoclonal antibodies. Nature 1980;287:332-3.

Krause JR. Carcinocythemia. Arch Pathol Lab Med 1979;103:98.

Ejeckam GC, Sogbein SK, McLeish WA. Carcinocythemia due to metastatic oat-cell carcinoma of the lung. Can Med Assoc J 1979;120:336-8.

Aboulafia DM. Carcinocythemia. A terminal manifestation of metastatic breast cancer. West J Med 1992;157:672-4.

Sile CC, Perry DJ, Nam L. Small cell carcinocythemia. Arch Pathol Lab Med 1999;123:426-8.

Misawa R, Kobayashi M, Ito M, Kato M, Uchikawa Y, Takagi S. Primary colonic signet ring cell carcinoma presenting carcinocythemia: An autopsy case. Case Rep Gastroenterol 2008;2:301-7.

Funaki NO, Tanaka J, Seto SI, Kasamatsu T, Kaido T, Imamura M. Hematogenous spreading of hepatocellular carcinoma cells: Possible participation in recurrence in the liver. Hepatology 1997;25:564-8.

Glumac N, Snoj M, Hocevar M, Novakovic S. Prognostic significance of tyrosinase mRNA detected by nested RT-PCR in patients with malignant melanoma. Neoplasma 2006;53:9-14.




 
Home     |     Articles in Press     |      About     |      Search     |      Current     |      Archives     |      Submit      |     Subscribe


 

     
       
       

Indian Journal of Medical Sciences, Quarterly, published by Medip Academy.     
This is an open-access journal, published articles are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.

website: www.ijmsweb.com   editorial contact: editor@ijmsweb.com

© Medip Academy. All Rights Reserved.