DOI: http://dx.doi.org/10.18203/issn.0019-5359.IndianJMedSci20170485

Pilot study of hepatitis b, c and human immunodeficiency viruses infections among patients with chronic liver diseases from north-east india attending a new tertiary care health set up at shillong

Jeetendra Gurung, Anil Chandra Phukan, Annie B. Khyriem, Kyrshanlang G. Lynrah

Abstract


Background: Chronic liver diseases (CLD) are major public health concerns in North-Eastern India. Association of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections in CLD patients result in atypical presentations with increased severity and duration of illness. Understanding of agent, host, clinical profiles and their co-relationship for better management and prevention of such diseases in the community are important challenges. Aims: To assess sero-prevalance of HBV, HCV, HIV and their co-infection/triple infection in CLD patients from North-East India. To determine risk factors predisposing to development of CLDs. To find out if any correlation exists between risk factors for CLDs and that of HBV/HCV/HIV infections. Materials And Methods: This study was conducted from December 2009 to June 2011 in North-Eastern Indira Gandhi Regional Institute of Health and Medical Sciences. Blood samples were collected from 57 clinically diagnosed CLD patients after obtaining Institutional ethical clearance. Detail clinical profile with relevant biochemical test results were recorded. Viral markers - hepatitis B surface antigen, hepatitis B e (HBe) antigen, anti-HBe and anti-HCV were assessed employing commercial ELISA kits. Specimens were subjected for detection and confirmation of HIV infection as per NACO Guidelines. Results: Male to female ratio was 1.85:1 with most cases in range of 31-50 years. HBV markers were detected in 35 (61.40%) and anti-HCV in 2 (3.5%) patients. Anti-HIV was reactive in 7 (12.28%) patients; 4 co-infected with HBV and 2 with HCV. Conclusion: HBV is still a major cause of CLD, followed by HCV in North-East India. Co-infection of HBV/HCV with HIV was low (7.14%) in comparison to rest of India. Confections of HIV with HBV/HCV in CLDs patients was observed to be major public health concern in terms of risk factors and transmission dynamics of these chronic diseases in North-East India.

 

Keywords


Chronic liver diseases, enzyme immunosorbent assays, hepatitis B virus, hepatitis C virus, human immunodeficiency virus

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References


Wanless IR. Physioanatomic consideration. In: Schiff ER, Sorrell MF, Maddrey WC, editors. Schiff’s Disease of the Liver. 8th ed. Philadelphia: Lippincott-Raven Publications; 1999. p. 3-37.

Valsamakis A. Molecular testing in the diagnosis and management of chronic hepatitis B. Clin Microbiol Rev 2007;20:426-39.

Datta S. An overview of molecular epidemiology of hepatitis B virus (HBV) in India. Virol J 2008;5:156.

Rantala M, van de Laar MJ. Surveillance and epidemiology of hepatitis B and C in Europe: A review. Euro Surveill 2008;13:1-8.

Chakravarti A, Rawat D, Jain M. A study on the perinatal transmission of the hepatitis B virus. Indian J Med Microbiol 2005;23:128-30.

Mathur M, Turbadkar D, Rele M. Prevalence of HIV infection in HBsAg positive cases. Indian J Med Microbiol 2002;20:225.

Gupta P, Biswas D, Shukla I, Bal A. Need for routine screening of HBV and HDV in patients with cirrhosis of the liver. Indian J Med Microbiol 2005;23:141-2.

Kumar A, Shukla I, Malik A. Co-infection with hepatitis B and human immunodeficiency viruses in patients of liver disease. Indian J Med Microbiol 2003;21:141-2.

Simmonds P, Mutimer D. Hepatitis C virus. In: Mahy BW, Meulen V, editors. Topley and Wilson’s Microbiology and Microbial Infections: Virology. 10th ed., Vol. 2. London: Hodder Arnold Publications; 2005. p. 1189-217.

Ayoola EA, al-Mofleh IA, al-Faleh FZ, al-Rashed R, Arif MA, Ramia S, et al. Prevalence of antibodies to hepatitis C virus among Saudi patients with chronic liver diseases. Hepatogastroenterology 1992;39:337-9.

Singh V, Katyal R, Kochhar RK, Bhasin DK, Aggarwal RP. Study of hepatitis B and C viral markers in patients of chronic liver disease. Indian J Med Microbiol 2004;22:269-70.

Arora U, Mann A. Prevalence of hepatitis B virus, hepatitis C virus and HIV in patients of chronic liver disease in amritsar. J Indian Acad Clin Med 2007;8:29-31.

Chakravarti A, Verma V. Prevalence of hepatitis C and B viral markers in patients with chronic liver disease: A study from Northern India. Indian J Med Microbiol 2005;23:273-4.

Arora DR, Sehgal R, Gupta N, Yadav A, Mishra N, Siwach SB. Prevalence of parenterally transmitted hepatitis viruses in clinically diagnosed cases of hepatitis. Indian J Med Microbiol 2005;23:44-7.

Jain M, Chakravarti A, Verma V, Bhalla P. Seroprevalence of hepatitis viruses in patients infected with the human immunodeficiency virus. Indian J Pathol Microbiol 2009;52:17-9.

Gupta S, Singh S. Hepatitis B and C virus co-infections in human immunodeficiency virus positive North Indian patients. World J Gastroenterol 2006;12:6879-83.

Bhattacharya S, Badrinath S, Hamide A, Sujatha S. Co-infection with hepatitis C virus and human immunodeficiency virus among patients with sexually transmitted diseases in Pondicherry, South India. Indian J Pathol Microbiol 2003;46:495-7.

Wong DK, Tanaka Y, Lai CL, Mizokami M, Fung J, Yuen MF. Hepatitis B virus core-related antigens as markers for monitoring chronic hepatitis B infection. J Clin Microbiol 2007;45:3942-7.

Kimura T, Rokuhara A, Sakamoto Y, Yagi S, Tanaka E, Kiyosawa K, et al. Sensitive enzyme immunoassay for hepatitis B virus core- related antigens and their correlation to virus load. J Clin Microbiol 2002;40:439-45.

Huang CS, Ho MS, Yang CS, Lee CL, Tan CA. Hepatitis C markers in hemodialysis patients. J Clin Microbiol 1993;31:1764-9.

Vallari DS, Jett BW, Alter HJ, Mimms LT, Holzman R, Shih JW. Serological markers of posttransfusion hepatitis C viral infection. J Clin Microbiol 1992;30:552-6.

Weber B, Bayer A, Kirch P, SchlüterV, Schlieper D, Melchior W. Improved detection of hepatitis B virus surface antigen by a new rapid automated assay. J Clin Microbiol 1999;37:2639-47.

National AIDS Control Organisation, Ministry of Health and Family Welfare, Govt. of India. Manual on Quality Standards for HIV Testing Laboratories. New Delhi: National AIDS Control Organisation, Ministry of Health and Family Welfare; 2007. p. 6-15.

Wang CS, Chang TT, Yao WJ, Chou P. Comparison of hepatitis B virus and hepatitis C virus prevalence and risk factors in a community-based study. Am J Trop Med Hyg 2002;66:389-93.

Zoulim F, Mimms L, Floreani M, Pichoud C, Chemin I, Kay A, et al. New assays for quantitative determination of viral markers in management of chronic hepatitis B virus infection. J Clin Microbiol 1992;30:1111-9.

Zhang JY, Dai M, Wang X, Lu WQ, Li DS, Zhang MX, et al. A case-control study of hepatitis B and C virus infection as risk factors for hepatocellular carcinoma in Henan, China. Int J Epidemiol 1998;27:574-8.

Fabrizi F, Pozzi C, Farina M, Dattolo P, Lunghi G, Badalamenti S, et al. Hepatitis C virus infection and acute or chronic glomerulonephritis: An epidemiological and clinical appraisal. Nephrol Dial Transplant 1998;13:1991-7.

Pahuja S, Sharma M, Baitha B, Jain M. Prevalence and trends of markers of hepatitis C virus, hepatitis B virus and human immunodeficiency virus in Delhi blood donors: a hospital based study. Jpn J Infect Dis 2007;60:389-91.

Wolfram HG, Kann M. Hepatitis B. In: Mahy BW, Meulen V, editors. Topley and Wilson’s Microbiology and Microbial Infections: Virology. 10th ed., Vol. 2. London: Hodder Arnold Publications; 2005. p. 1226-61.

Changotra H, Dwivedi A, Nayyar AK, Sehajpal PK. Diagnosing different stages of hepatitis B infection using a competitive polymerase chain reaction assay. Indian J Med Microbiol 2008;26:138-42.

Muralidhar S, Bala M, Jain RK, Malhotra M, Ray K. Hepatitis B and C positivity in various Categories of Human Immunodeficiency Virus seropositive individuals in a regional —uAn eight-year evaluation of trends and risk factors. Am Med J 2010;1:77-82.

Polilli E, Sozio F, Mazzotta E, Pieri A, Alterio L, Placido E, et al. Fatal reactivation of HBV and HDV during a long-lasting interruption of HAART in a patient co-infected with HIV, HCV, HBV and HDV. Infez Med 2010;18:43-7.




 
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